Publications

Year 2021

  • Bidaud I, D'Souza A, Forte G, Torre E, Greuet D, Thirard S, Anderson C, Chung You Chong A, Torrente AG, Roussel J, Wickman K, Boyett MR, Mangoni ME, Mesirca P. Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia. Front Physiol. 2021 Jan 20;11:519382. doi: 10.3389/fphys.2020.519382. eCollection 2020. PMID: 33551824

  • Baudot M, Torre E, Bidaud I, Louradour J, Torrente AG, Fossier L, Talssi L, Nargeot J, Barrère-Lemaire S, Mesirca P, Mangoni ME. Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity. Sci Rep. 2020 Nov 3;10(1):18906. doi: 10.1038/s41598-020-76049-7. PMID: 33144668.

  • *Boyett, M. R Yanni, J., Tellez, J., Bucchi, A., Mesirca, P., Cai, X. Logantha, Sjrj, Wilson, C., Anderson, C., Ariyaratnam, J., Stuart, L., Nakao, S., Abd Allah, E., Jones, S., Lancaster, M., Stephenson, R., Chandler, N., Smith, M., Bussey, C., Monfredi, O., Morris, G., Billeter, R., Mangoni, M. E., Zhang, H., Hart, G., D'Souza, A. Regulation of sinus node pacemaking and atrioventricular node conduction by HCN channels in health and disease. Prog Biophys Mol Biol, doi:10.1016/j.pbiomolbio.2021.06.008 (2021).

  • DiFrancesco, M. L., Mesirca, P., Bidaud, I., Isbrandt, D., Mangoni M. E. The funny current in genetically modified mice. Prog Biophys Mol Biol, doi:10.1016/j.pbiomolbio.2021.06.003 (2021). Review article.

  • Kalyanasundaram A, Li N, Gardner ML, Artiga EJ, Hansen BJ, Webb A, Freitas MA, Pietrzak M, Whitson BA, Mokadam NA, Janssen PML, Mohler PJ, Fedorov VV. Fibroblast-Specific Proteo-Transcriptomes Reveal Distinct Fibrotic Signatures of Human Sinoatrial Node in Non-Failing and Failing Hearts. Circulation. 2021 Apr 20. doi: 10.1161/CIRCULATIONAHA.120.051583. Online ahead of print. PMID: 33874740

  • Hyman, M. C., Papireddy, M. & Frankel, D. S. Paroxysmal Atrioventricular Block. JAMA Intern Med 181, 1108-1109, doi:10.1001/jamainternmed.2021.2526 (2021).

  • *Mesirca P, Nakao S, Nissen SD, Forte G, Anderson C, Trussell T, Li J, Cox C, Zi M, Logantha SJR, Yaar S, Carstensen H, Bidaud I, Stuart L, Soattin L, Morris GM, da Costa Martins PA, Cartwright EJ, Oceandy D, Mangoni ME, Jespersen T, Buhl R, Dobrzynski H, Boyett MR, D'Souza A. Intrinsic Electrical Remodeling Underlies Atrioventricular Block in Athletes. Circ Res. 2021 Apr 14. doi: 10.1161/CIRCRESAHA.119.316386. Online ahead of print. PMID: 33849278

  • *Mesirca P, Fedorov VV, Hund TJ, Torrente AG, Bidaud I, Mohler PJ, Mangoni ME. Pharmacologic Approach to Sinoatrial Node Dysfunction. Annu Rev Pharmacol Toxicol. 2021 Jan 6; 6:757-778. doi: 10.1146/annurev-pharmtox-031120-115815. Epub 2020 Oct 5. PMID: 33017571. Review article.

  • Pineda S, Nikolova-Krstevski V, Leimena C, Atkinson AJ, Altekoester AK, Cox CD, Jacoby A, Huttner IG, Ju YK, Soka M, Ohanian M, Trivedi G, Kalvakuri S, Birker K, Johnson R, Molenaar P, Kuchar D, Allen DG, van Helden DF, Harvey RP, Hill AP, Bodmer R, Vogler G, Dobrzynski H, Ocorr K, Fatkin D. Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk. Circ Genom Precis Med. 2021 Feb 25. doi: 10.1161/CIRCGEN.120.003144. Epub ahead of print. PMID: 33629867.

  • Saponaro, A. Bauer, D., Giese, M. H., Swuec, P., Porro, A., Gasparri, F., Sharifzadeh, A. S., Chaves-Sanjuan, A., Alberio, L., Parisi, G., Cerutti, G., Clarke, O. B., Hamacher, K., Colecraft, H. M., Mancia, F., Hendrickson, W. A., Siegelbaum, S. A., DiFrancesco, D., Bolognesi, M., Thiel, G., Santoro, B., Moroni, A. Gating movements and ion permeation in HCN4 pacemaker channels. Mol Cell 81, 2929-2943 e2926, doi:10.1016/j.molcel.2021.05.033 (2021).

  • Soattin L, Borbas Z, Caldwell J, Prendergast B, Vohra A, Saeed Y, Hoschtitzky A, Yanni J, Atkinson A, Logantha SJ, Borbas B, Garratt C, Morris GM, Dobrzynski H. Structural and Functional Properties of Subsidiary Atrial Pacemakers in a Goat Model of Sinus Node Disease. Front Physiol. 2021 Mar 4;12:592229. doi: 10.3389/fphys.2021.592229. PMID: 33746765; PMCID: PMC7969524.

  • Turner, D. Kang, C., Mesirca, P., Hong, J., Mangoni, M. E., Glukhov, A. V. Electrophysiological and Molecular Mechanisms of Sinoatrial Node Mechanosensitivity. Front Cardiovasc Med 8, 662410, doi:10.3389/fcvm.2021.662410 (2021). Review article.

  • *Wallace MJ, El Refaey M, Mesirca P, Hund TJ, Mangoni ME, Mohler PJ. Genetic Complexity of Sinoatrial Node Dysfunction. Front Genet. 2021 Apr 1;12:654925. doi: 10.3389/fgene.2021.654925. eCollection 2021. PMID: 33868385. Review article.

  • Wang Y, Anderson C, Dobrzynski H, Hart G, D'Souza A, Boyett MR. RNAseq shows an all-pervasive day-night rhythm in the transcriptome of the pacemaker of the heart. Sci Rep. 2021 Feb 11;11(1):3565. doi: 10.1038/s41598-021-82202-7. PMID: 33574422; PMCID: PMC7878777.

  • Kuzmin VS, Ivanova AD, Filatova TS, Pustovit KB, Kobylina AA, Atkinson AJ, Petkova M, Voronkov YI, Abramochkin DV, Dobrzynski H. Micro-RNA 133a-3p induces repolarization abnormalities in atrial myocardium and modulates ventricular electrophysiology affecting ICa,L and Ito currents. Eur J Pharmacol. 2021 Oct 5;908:174369. doi: 10.1016/j.ejphar.2021.174369. Epub 2021 Jul 24. PMID: 34310913.

  • Aminu, A., Petkova, M., Chen, W., Yin, Z., Kuzmin, V. S., Atkinson, A., & Dobrzynski, H. (2021). MiR-486-3p and MiR-938 –Important Inhibitors of Pacemaking Ion Channels and/or Markers of Immune Cells. Applied Sciences.

  • Logantha SJRJ, Cai XJ, Yanni J, Jones CB, Stephenson RS, Stuart L, Quigley G, Monfredi O, Nakao S, Oh IY, Starborg T, Kitmitto A, Vohra A, Hutcheon RC, Corno AF, Jarvis JC, Dobrzynski H, Boyett MR, Hart G. Remodeling of the Purkinje Network in Congestive Heart Failure in the Rabbit. Circ Heart Fail. 2021 Jul;14(7):e007505. doi: 10.1161/CIRCHEARTFAILURE.120.007505. Epub 2021 Jun 30. PMID: 34190577; PMCID: PMC8288482.

Year 2020

  • Bidaud I, Chong ACY, Carcouet A, Waard S, Charpentier F, Ronjat M, Waard M, Isbrandt D, Wickman K, Vincent A, Mangoni ME, Mesirca P. Inhibition of G protein-gated K+ channels by tertiapin-Q rescues sinus node dysfunction and atrioventricular conduction in mouse models of primary bradycardia. Sci Rep. 2020 Jun 17;10(1):9835. doi: 10.1038/s41598-020-66673-8. PMID: 32555258.

  • Baudot M, Torre E, Bidaud I, Louradour J, Torrente AG, Fossier L, Talssi L, Nargeot J, Barrère-Lemaire S, Mesirca P, Mangoni ME. Concomitant genetic ablation of L-type Cav1.3 (α1D) and T-type Cav3.1 (α1G) Ca2+ channels disrupts heart automaticity. Sci Rep. 2020 Nov 3;10(1):18906. doi: 10.1038/s41598-020-76049-7. PMID: 33144668.

  • De Waard S, Montnach J, Cortinovis C, Chkir O, Erfanian M, Hulin P, Gaborit N, Lemarchand P, Mesirca P, Bidaud I, Mangoni ME, De Waard M, Ronjat M. Maurocalcin and its analog MCaE12A facilitate Ca2+ mobilization in cardiomyocytes. Biochem J. 2020 Oct 30;477(20):3985-3999. doi: 10.1042/BCJ20200206. PMID: 33034621

  • DiFrancesco D. A Brief History of Pacemaking. Front Physiol. 2020 Jan 22;10:1599. doi: 10.3389/fphys.2019.01599. eCollection 2019. PMID: 32038284. Review article.

  • *D'Souza A, Wang Y, Anderson C, Bucchi A, Baruscotti M, Olieslagers S, Mesirca P, Johnsen AB, Mastitskaya S, Ni H, Zhang Y, BmBCh NB, Cox C, Wegner S, Bano-Otalora B, Petit C, Gill E, Logantha SJRJ, Dobrzynski H, Ashton N, Hart G, Zhang R, Zhang H, Cartwright EJ, Wisloff U, Mangoni ME, da Costa Martins PA, Piggins HD, DiFrancesco D, Boyett MR. A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate. Heart Rhythm. 2020 Dec 3:S1547-5271(20)31130-9. doi: 10.1016/j.hrthm.2020.11.026. Epub ahead of print. PMID: 33278629.

  • Lu Z, Wang HZ, Gordon CR, Ballou LM, Lin RZ, Cohen IS. Regulation of HCN2 Current by PI3K/Akt Signaling. Front Physiol. 2020 Nov 9;11:587040. doi: 10.3389/fphys.2020.587040. eCollection 2020. PMID: 33240105

  • Nakao S, Atkinson AJ, Motomochi T, Fukunaga D, Dobrzynski H. Common arterial trunk in a cat: a high-resolution morphological analysis with micro-computed tomography. J Vet Cardiol. 2020 Dec 21;34:8-15. doi: 10.1016/j.jvc.2020.12.003. Epub ahead of print. PMID: 33486210.

  • Yanni J, D'Souza A, Wang Y, Li N, Hansen BJ, Zakharkin SO, Smith M, Hayward C, Whitson BA, Mohler PJ, Janssen PML, Zeef L, Choudhury M, Zi M, Cai X, Logantha SJRJ, Nakao S, Atkinson A, Petkova M, Doris U, Ariyaratnam J, Cartwright EJ, Griffiths-Jones S, Hart G, Fedorov VV, Oceandy D, Dobrzynski H, Boyett MR. Silencing miR-370-3p rescues funny current and sinus node function in heart failure. Sci Rep. 2020 Jul 9;10(1):11279. doi: 10.1038/s41598-020-67790-0. PMID: 32647133; PMCID: PMC7347645.

  • Torrente AG, Mesirca P, Bidaud I, Mangoni ME. Channelopathies of voltage-gated L-type Cav1.3/α1D and T-type Cav3.1/α1G Ca2+ channels in dysfunction of heart automaticity. Pflugers Arch. 2020 Jul;472(7):817-830. doi: 10.1007/s00424-020-02421-1. Epub 2020 Jun 29. PMID: 32601767. Review article.

  • *Petkova M, Atkinson AJ, Yanni J, Stuart L, Aminu AJ, Ivanova AD, Pustovit KB, Geragthy C, Feather A, Li N, Zhang Y, Oceandy D, Perde F, Molenaar P, D'Souza A, Fedorov VV, Dobrzynski H. Identification of Key Small Non-Coding MicroRNAs Controlling Pacemaker Mechanisms in the Human Sinus Node. J Am Heart Assoc. 2020 Oct 20;9(20):e016590. doi: 10.1161/JAHA.120.016590. Epub 2020 Oct 16. PMID: 33059532; PMCID: PMC7763385.

  • Nakao S, Atkinson AJ, Motomochi T, Fukunaga D, Dobrzynski H. Common arterial trunk in a cat: a high-resolution morphological analysis with micro-computed tomography. J Vet Cardiol. 2021 Apr;34:8-15. doi: 10.1016/j.jvc.2020.12.003. Epub 2020 Dec 21. PMID: 33486210.